A Missense Mutation in the fabB (β-Ketoacyl-Acyl Carrier Protein Synthase I) Gene Confers Thiolactomycin Resistance to Escherichia coli

Thiolactomycin (TLM) is an antibiotic that inhibits bacterial type II fatty acid synthesis at the condensing enzyme step, and β-ketoacyl-acyl carrier protein synthase I (FabB) is the relevant target in Escherichia coli. TLM resistance is associated with the upregulation of efflux pumps. Therefore, a...

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Bibliografske podrobnosti

izdano v:	Antimicrob Agents Chemother
Principais autores:	Jackowski, Suzanne, Zhang, Yong-Mei, Price, Allen C., White, Stephen W., Rock, Charles O.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2002
Teme:	Mechanisms of Resistance
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127160/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11959552/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.5.1246-1252.2002
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