Phosphorylation of β-d-Ribosylbenzimidazoles Is Not Required for Activity against Human Cytomegalovirus

We have previously reported that 2,5,6-trichloro-1-(β-d-ribofuranosyl)benzimidazole (TCRB) and its 2-bromo analog (2-bromo-5,6-dichloro-1-(β-d-ribofuranosy)benzimidazole [BDCRB]) are potent and selective inhibitors of human cytomegalovirus (HCMV) replication that block viral DNA maturation via HCMV...

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Autori principali: Krosky, Paula M., Borysko, Katherine Z., Nassiri, M. Reza, Devivar, Rodrigo V., Ptak, Roger G., Davis, Michelle G., Biron, Karen K., Townsend, Leroy B., Drach, John C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC127035/
https://ncbi.nlm.nih.gov/pubmed/11796361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.2.478-486.2002
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