Nonnucleoside Pyrrolopyrimidines with a Unique Mechanism of Action against Human Cytomegalovirus

Based upon a prior study which evaluated a series of nonnucleoside pyrrolo[2,3-d]pyrimidines as inhibitors of human cytomegalovirus (HCMV), we have selected three active analogs for detailed study. In an HCMV plaque-reduction assay, compounds 828, 951, and 1028 had 50% inhibitory concentrations (IC(...

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Detalhes bibliográficos
Main Authors: Jacobson, Jennie G., Renau, Thomas E., Nassiri, M. Reza, Sweier, Dominica G., Breitenbach, Julie M., Townsend, Leroy B., Drach, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC89386/
https://ncbi.nlm.nih.gov/pubmed/10428908
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