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Levofloxacin Penetration into Epithelial Lining Fluid as Determined by Population Pharmacokinetic Modeling and Monte Carlo Simulation

Levofloxacin was administered orally to steady state to volunteers randomly in doses of 500 and 750 mg. Plasma and epithelial lining fluid (ELF) samples were obtained at 4, 12, and 24 h after the final dose. All data were comodeled in a population pharmacokinetic analysis employing BigNPEM. Penetrat...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Drusano, G. L., Preston, S. L., Gotfried, M. H., Danziger, L. H., Rodvold, K. A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127017/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11796385/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.2.586-589.2002
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