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Levofloxacin Penetration into Epithelial Lining Fluid as Determined by Population Pharmacokinetic Modeling and Monte Carlo Simulation

Levofloxacin was administered orally to steady state to volunteers randomly in doses of 500 and 750 mg. Plasma and epithelial lining fluid (ELF) samples were obtained at 4, 12, and 24 h after the final dose. All data were comodeled in a population pharmacokinetic analysis employing BigNPEM. Penetrat...

詳細記述

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書誌詳細
主要な著者: Drusano, G. L., Preston, S. L., Gotfried, M. H., Danziger, L. H., Rodvold, K. A.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC127017/
https://ncbi.nlm.nih.gov/pubmed/11796385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.2.586-589.2002
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