Single-Dose Intraperitoneal Magainins Improve Survival in a Gram-Negative-Pathogen Septic Shock Rat Model

The therapeutic efficacies of three polycationic peptides selected among the class of the magainins (magainin I, magainin II, and magainin II amide), alone and combined with piperacillin, were investigated in a rat model of septic shock. Rats were given an intraperitoneal injection of 2 × 10(10) CFU...

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Autors principals: Cirioni, Oscar, Giacometti, Andrea, Ghiselli, Roberto, Mocchegiani, Federico, Fineo, Anna, Orlando, Fiorenza, Prete, Maria Simona Del, Rocchi, Marco, Saba, Vittorio, Scalise, Giorgio
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC127007/
https://ncbi.nlm.nih.gov/pubmed/11751118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.1.101-104.2002
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