Single-Dose Intraperitoneal Magainins Improve Survival in a Gram-Negative-Pathogen Septic Shock Rat Model

The therapeutic efficacies of three polycationic peptides selected among the class of the magainins (magainin I, magainin II, and magainin II amide), alone and combined with piperacillin, were investigated in a rat model of septic shock. Rats were given an intraperitoneal injection of 2 × 10(10) CFU...

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Detalhes bibliográficos
Main Authors: Cirioni, Oscar, Giacometti, Andrea, Ghiselli, Roberto, Mocchegiani, Federico, Fineo, Anna, Orlando, Fiorenza, Prete, Maria Simona Del, Rocchi, Marco, Saba, Vittorio, Scalise, Giorgio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127007/
https://ncbi.nlm.nih.gov/pubmed/11751118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.1.101-104.2002
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