Single-Dose Intraperitoneal Magainins Improve Survival in a Gram-Negative-Pathogen Septic Shock Rat Model

The therapeutic efficacies of three polycationic peptides selected among the class of the magainins (magainin I, magainin II, and magainin II amide), alone and combined with piperacillin, were investigated in a rat model of septic shock. Rats were given an intraperitoneal injection of 2 × 10(10) CFU...

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Bibliographische Detailangaben
Hauptverfasser: Cirioni, Oscar, Giacometti, Andrea, Ghiselli, Roberto, Mocchegiani, Federico, Fineo, Anna, Orlando, Fiorenza, Prete, Maria Simona Del, Rocchi, Marco, Saba, Vittorio, Scalise, Giorgio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC127007/
https://ncbi.nlm.nih.gov/pubmed/11751118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.1.101-104.2002
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