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Polyglutamine aggregation nucleation: Thermodynamics of a highly unfavorable protein folding reaction
Polyglutamine (polyGln) aggregation is implicated in the disease progression of Huntington's disease and other expanded CAG repeat diseases. PolyGln aggregation in vitro follows a simple nucleated growth polymerization pathway without apparent complications such as populated intermediates, alte...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2005
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1266079/ https://ncbi.nlm.nih.gov/pubmed/16230628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501651102 |
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