Predominant selection of T cells specific for the glycosylated collagen type II epitope (263–270) in humanized transgenic mice and in rheumatoid arthritis

Rheumatoid arthritis (RA) is associated with certain MHC class II alleles and is characterized by a chronic autoimmune response in the joints. Using transgenic mice expressing human DR4 (DRB1*0401) and human CD4, but lacking endogenous MHC class II, we show that posttranslational glycosylation of ty...

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Bibliografski detalji
Glavni autori: Bäcklund, Johan, Carlsen, Stefan, Höger, Torsten, Holm, Björn, Fugger, Lars, Kihlberg, Jan, Burkhardt, Harald, Holmdahl, Rikard
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2002
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC126607/
https://ncbi.nlm.nih.gov/pubmed/12089323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132254199
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