Predominant selection of T cells specific for the glycosylated collagen type II epitope (263–270) in humanized transgenic mice and in rheumatoid arthritis

Rheumatoid arthritis (RA) is associated with certain MHC class II alleles and is characterized by a chronic autoimmune response in the joints. Using transgenic mice expressing human DR4 (DRB1*0401) and human CD4, but lacking endogenous MHC class II, we show that posttranslational glycosylation of ty...

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Autores principales: Bäcklund, Johan, Carlsen, Stefan, Höger, Torsten, Holm, Björn, Fugger, Lars, Kihlberg, Jan, Burkhardt, Harald, Holmdahl, Rikard
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2002
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC126607/
https://ncbi.nlm.nih.gov/pubmed/12089323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132254199
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