Integrin α4β1 Promotes Focal Adhesion Kinase-Independent Cell Motility via α4 Cytoplasmic Domain-Specific Activation of c-Src

The fibronectin binding integrins α5β1 and α4β1 generate signals pivotal for cell migration through distinct yet undefined mechanisms. For α5β1, β1-mediated activation of focal adhesion kinase (FAK) promotes c-Src recruitment to FAK and the formation of a FAK-Src signaling complex. Herein, we show t...

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Detalhes bibliográficos
Main Authors: Hsia, Datsun A., Lim, Ssang-Taek, Bernard-Trifilo, Joie A., Mitra, Satyajit K., Tanaka, Sakae, den Hertog, Jeroen, Streblow, Daniel N., Ilic, Dusko, Ginsberg, Mark H., Schlaepfer, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265817/
https://ncbi.nlm.nih.gov/pubmed/16227616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.21.9700-9712.2005
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