Differential regulation of cell motility and invasion by FAK

Cell migration and invasion are fundamental components of tumor cell metastasis. Increased focal adhesion kinase (FAK) expression and tyrosine phosphorylation are connected with elevated tumorigenesis. Null mutation of FAK results in embryonic lethality, and FAK(−/−) fibroblasts exhibit cell migrati...

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Detalhes bibliográficos
Main Authors: Hsia, Datsun A., Mitra, Satyajit K., Hauck, Christof R., Streblow, Daniel N., Nelson, Jay A., Ilic, Dusko, Huang, Shuang, Li, Erguang, Nemerow, Glen R., Leng, Jay, Spencer, Kathryn S.R., Cheresh, David A., Schlaepfer, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173366/
https://ncbi.nlm.nih.gov/pubmed/12615911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200212114
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