Differential regulation of cell motility and invasion by FAK

Cell migration and invasion are fundamental components of tumor cell metastasis. Increased focal adhesion kinase (FAK) expression and tyrosine phosphorylation are connected with elevated tumorigenesis. Null mutation of FAK results in embryonic lethality, and FAK(−/−) fibroblasts exhibit cell migrati...

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Main Authors: Hsia, Datsun A., Mitra, Satyajit K., Hauck, Christof R., Streblow, Daniel N., Nelson, Jay A., Ilic, Dusko, Huang, Shuang, Li, Erguang, Nemerow, Glen R., Leng, Jay, Spencer, Kathryn S.R., Cheresh, David A., Schlaepfer, David D.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2003
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173366/
https://ncbi.nlm.nih.gov/pubmed/12615911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200212114
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