Nucleophosmin Is Required for DNA Integrity and p19(Arf) Protein Stability

Nucleophosmin (NPM) is a nucleolar phosphoprotein that binds the tumor suppressors p53 and p19(Arf) and is thought to be indispensable for ribogenesis, cell proliferation, and survival after DNA damage. The NPM gene is the most frequent target of genetic alterations in leukemias and lymphomas, thoug...

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Main Authors: Colombo, Emanuela, Bonetti, Paola, Lazzerini Denchi, Eros, Martinelli, Paola, Zamponi, Raffaella, Marine, Jean-Christophe, Helin, Kristian, Falini, Brunangelo, Pelicci, Pier Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265791/
https://ncbi.nlm.nih.gov/pubmed/16199867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.20.8874-8886.2005
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