Deregulated E2F Activity Induces Hyperplasia and Senescence-Like Features in the Mouse Pituitary Gland

The retinoblastoma gene, RB1, is one of the most frequently mutated genes in human cancer. Rb heterozygous mice develop pituitary tumors with 100% incidence, and the E2F transcription factors are required for this. To assess whether deregulated E2F activity is sufficient to induce pituitary tumors,...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Denchi, Eros Lazzerini, Attwooll, Claire, Pasini, Diego, Helin, Kristian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2005
Gaiak:
Gene Expression
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061636/
https://ncbi.nlm.nih.gov/pubmed/15767672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.7.2660-2672.2005
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