L1 Is Sequentially Processed by Two Differently Activated Metalloproteases and Presenilin/γ-Secretase and Regulates Neural Cell Adhesion, Cell Migration, and Neurite Outgrowth

The immunoglobulin superfamily recognition molecule L1 plays important functional roles in the developing and adult nervous system. Metalloprotease-mediated cleavage of this adhesion molecule has been shown to stimulate cellular migration and neurite outgrowth. We demonstrate here that L1 cleavage i...

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Autores principales: Maretzky, Thorsten, Schulte, Marc, Ludwig, Andreas, Rose-John, Stefan, Blobel, Carl, Hartmann, Dieter, Altevogt, Peter, Saftig, Paul, Reiss, Karina
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Intracellular Trafficking
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265787/
https://ncbi.nlm.nih.gov/pubmed/16199880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.20.9040-9053.2005
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