ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and β-catenin translocation

E-cadherin controls a wide array of cellular behaviors, including cell-cell adhesion, differentiation, and tissue development. We show here that E-cadherin is cleaved specifically by ADAM (a disintegrin and metalloprotease) 10 in its ectodomain. Analysis of ADAM10-deficient fibroblasts, inhibitor st...

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Detalhes bibliográficos
Main Authors: Maretzky, Thorsten, Reiss, Karina, Ludwig, Andreas, Buchholz, Julian, Scholz, Felix, Proksch, Erhardt, de Strooper, Bart, Hartmann, Dieter, Saftig, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1166595/
https://ncbi.nlm.nih.gov/pubmed/15958533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500918102
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