Centrosomal Microtubule Nucleation Activity Is Inhibited by BRCA1-Dependent Ubiquitination

In this study we find that the function of BRCA1 inhibits the microtubule nucleation function of centrosomes. In particular, cells in early S phase have quiescent centrosomes due to BRCA1 activity, which inhibits the association of γ-tubulin with centrosomes. We find that modification of either of t...

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Autors principals: Sankaran, Satish, Starita, Lea M., Groen, Aaron C., Ko, Min Ji, Parvin, Jeffrey D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265743/
https://ncbi.nlm.nih.gov/pubmed/16166645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.19.8656-8668.2005
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