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Centrosomal Microtubule Nucleation Activity Is Inhibited by BRCA1-Dependent Ubiquitination
In this study we find that the function of BRCA1 inhibits the microtubule nucleation function of centrosomes. In particular, cells in early S phase have quiescent centrosomes due to BRCA1 activity, which inhibits the association of γ-tubulin with centrosomes. We find that modification of either of t...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology
2005
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1265743/ https://ncbi.nlm.nih.gov/pubmed/16166645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.19.8656-8668.2005 |
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