BRCA1-Dependent Ubiquitination of γ-Tubulin Regulates Centrosome Number

Proper centrosome duplication and spindle formation are crucial for prevention of chromosomal instability, and BRCA1 plays a role in this process. In this study, transient inhibition of BRCA1 function in cell lines derived from mammary tissue caused rapid amplification and fragmentation of centrosom...

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Detalhes bibliográficos
Main Authors: Starita, Lea M., Machida, Yuka, Sankaran, Satish, Elias, Joshua E., Griffin, Karen, Schlegel, Brian P., Gygi, Steven P., Parvin, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC516733/
https://ncbi.nlm.nih.gov/pubmed/15367667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.19.8457-8466.2004
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