BRCA1 Regulates γ-Tubulin Binding to Centrosomes

Centrosomes are the cellular organelles that nucleate microtubules (MTs) via the activity of gamma-tubulin ring complex(s) (γTuRC) bound to the pericentriolar material of the centrosomes. BRCA1, the breast and ovarian cancer specific tumor suppressor, inhibits centrosomal MT nucleation via its ubiqu...

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Main Authors: Sankaran, Satish, Crone, Donna E., Palazzo, Robert E., Parvin, Jeffrey D.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643382/
https://ncbi.nlm.nih.gov/pubmed/18087219
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