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A novel uracil-DNA glycosylase with broad substrate specificity and an unusual active site

Uracil-DNA glycosylases (UDGs) catalyse the removal of uracil by flipping it out of the double helix into their binding pockets, where the glycosidic bond is hydrolysed by a water molecule activated by a polar amino acid. Interestingly, the four known UDG families differ in their active site make-up...

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Bibliografski detalji
Glavni autori: Sartori, Alessandro A., Fitz-Gibbon, Sorel, Yang, Hanjing, Miller, Jeffrey H., Jiricny, Josef
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2002
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC126064/
https://ncbi.nlm.nih.gov/pubmed/12065430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf309
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