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A novel uracil-DNA glycosylase with broad substrate specificity and an unusual active site
Uracil-DNA glycosylases (UDGs) catalyse the removal of uracil by flipping it out of the double helix into their binding pockets, where the glycosidic bond is hydrolysed by a water molecule activated by a polar amino acid. Interestingly, the four known UDG families differ in their active site make-up...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2002
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC126064/ https://ncbi.nlm.nih.gov/pubmed/12065430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf309 |
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