Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes

Prion protein (PrP) is usually attached to membranes by a glycosylphosphatidylinositol-anchor that associates with detergent-resistant membranes (DRMs), or rafts. To model the molecular processes that might occur during the initial infection of cells with exogenous transmissible spongiform encephalo...

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Опубликовано в::	EMBO J
Главные авторы:	Baron, Gerald S., Wehrly, Kathy, Dorward, David W., Chesebro, Bruce, Caughey, Byron
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Publishing Group 2002
Предметы:	Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125906/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11867531/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.5.1031
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