Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein

The human cytomegalovirus gene products US2 and US11 induce proteasomal degradation of MHC class I heavy chains. We have generated an enhanced green fluorescent protein–class I heavy chain (EGFP–HC) chimeric molecule to study its dislocation and degradation in US2- and US11-expressing cells. The EGF...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Fiebiger, Edda, Story, Craig, Ploegh, Hidde L., Tortorella, Domenico
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2002
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125905/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11867532/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.5.1041
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