The ERAD inhibitor Eeyarestatin I is a bifunctional compound with a membrane-binding domain and a p97/VCP inhibitory group.

Protein homeostasis in the endoplasmic reticulum (ER) has recently emerged as a therapeutic target for cancer treatment. Disruption of ER homeostasis results in ER stress, which is a major cause of cell death in cells exposed to the proteasome inhibitor Bortezomib, an anti-cancer drug approved for t...

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Главные авторы:	Qiuyan Wang, Bidhan A Shinkre, Jin-gu Lee, Marc A Weniger, Yanfen Liu, Weiping Chen, Adrian Wiestner, William C Trenkle, Yihong Ye
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2010-11-01
Серии:	PLoS ONE
Online-ссылка:	http://europepmc.org/articles/PMC2993181?pdf=render
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