Calcineurin is essential for survival during membrane stress in Candida albicans

The immunosuppressants cyclosporin A (CsA) and FK506 inhibit the protein phosphatase calcineurin and block T-cell activation and transplant rejection. Calcineurin is conserved in microorganisms and plays a general role in stress survival. CsA and FK506 are toxic to several fungi, but the common huma...

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Publicado en:	EMBO J
Autores principales:	Cruz, M.Cristina, Goldstein, Alan L., Blankenship, Jill R., Del Poeta, Maurizio, Davis, Dana, Cardenas, Maria E., Perfect, John R., McCusker, John H., Heitman, Joseph
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Publishing Group 2002
Materias:	Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125859/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11847103/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.4.546
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