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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Histone deacetylases (HDACs) play important roles in transcriptional regulation and pathogenesis of cancer. Thus, HDAC inhibitors are candidate drugs for differentiation therapy of cancer. Here, we show that the well-tolerated antiepileptic drug valproic acid is a powerful HDAC inhibitor. Valproic a...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2001
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125788/ https://ncbi.nlm.nih.gov/pubmed/11742974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.24.6969 |
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