Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

Histone deacetylases (HDACs) play important roles in transcriptional regulation and pathogenesis of cancer. Thus, HDAC inhibitors are candidate drugs for differentiation therapy of cancer. Here, we show that the well-tolerated antiepileptic drug valproic acid is a powerful HDAC inhibitor. Valproic a...

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Bibliographic Details
Main Authors: Göttlicher, Martin, Minucci, Saverio, Zhu, Ping, Krämer, Oliver H., Schimpf, Annemarie, Giavara, Sabrina, Sleeman, Jonathan P., Lo Coco, Francesco, Nervi, Clara, Pelicci, Pier Giuseppe, Heinzel, Thorsten
Format: Artigo
Language:Inglês
Published: Oxford University Press 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC125788/
https://ncbi.nlm.nih.gov/pubmed/11742974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.24.6969
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