Stepwise activation of the immunoglobulin µ heavy chain gene locus
The immunoglobulin heavy chain (IgH) gene locus spans several megabases. We show that IgH activation during B-cell differentiation, as measured by histone acetylation, occurs in discrete, independently regulated domains. Initially, a 120 kb domain of germline DNA is hyperacetylated, that extends fro...
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| Опубликовано в:: | EMBO J |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125735/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11707410/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.22.6394 |
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