Matrix Attachment Region-Dependent Function of the Immunoglobulin μ Enhancer Involves Histone Acetylation at a Distance without Changes in Enhancer Occupancy

Nuclear matrix attachment regions (MARs), which flank the immunoglobulin μ heavy-chain enhancer on either side, are required for the activation of the distal variable-region (V(H)) promoter in transgenic mice. Previously, we have shown that the MARs extend a local domain of chromatin accessibility a...

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Detalhes bibliográficos
Main Authors: Fernández, Luis A., Winkler, Michael, Grosschedl, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC88794/
https://ncbi.nlm.nih.gov/pubmed/11113195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.1.196-208.2001
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