IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding

The proinflammatory cytokine interleukin 17 (IL-17) is the founding member of a family of secreted proteins that elicit potent cellular responses. We report a novel human IL-17 homolog, IL-17F, and show that it is expressed by activated T cells, can stimulate production of other cytokines such as IL...

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Hauptverfasser: Hymowitz, Sarah G., Filvaroff, Ellen H., Yin, JianPing, Lee, James, Cai, Liping, Risser, Philip, Maruoka, Miko, Mao, Weiguang, Foster, Jessica, Kelley, Robert F., Pan, Guohua, Gurney, Austin L., de Vos, Abraham M., Starovasnik, Melissa A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2001
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC125646/
https://ncbi.nlm.nih.gov/pubmed/11574464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.19.5332
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