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Chemical Synthesis, Backbone Cyclization and Oxidative Folding of Cystine-knot Peptides — Promising Scaffolds for Applications in Drug Design

Cystine-knot peptides display exceptional structural, thermal, and biological stability. Their eponymous motif consists of six cysteine residues that form three disulfide bonds, resulting in a notably rigid structural core. Since they highly tolerate either rational or combinatorial changes in their...

詳細記述

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書誌詳細
出版年:Molecules
主要な著者: Reinwarth, Michael, Nasu, Daichi, Kolmar, Harald, Avrutina, Olga
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6268209/
https://ncbi.nlm.nih.gov/pubmed/23095896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules171112533
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