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Fragmentation Follows Structure: Top-Down Mass Spectrometry Elucidates the Topology of Engineered Cystine-Knot Miniproteins

Over the last decades the field of pharmaceutically relevant peptides has enormously expanded. Among them, several peptide families exist that contain three or more disulfide bonds. In this context, elucidation of the disulfide patterns is extremely important as these motifs are often prerequisites...

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Bibliografiske detaljer
Main Authors: Reinwarth, Michael, Avrutina, Olga, Fabritz, Sebastian, Kolmar, Harald
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4193770/
https://ncbi.nlm.nih.gov/pubmed/25303319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108626
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