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Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment
Fluid shear stress is a critical determinant of vascular remodeling and atherogenesis. Both integrins and the small GTPase Rho are implicated in endothelial cell responses to shear but the mechanisms are poorly understood. We now show that shear stress rapidly stimulates conformational activation of...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125600/ https://ncbi.nlm.nih.gov/pubmed/11532928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.17.4639 |
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