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Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression

Hemodynamic shear stress is a fundamental determinant of vascular remodeling and atherogenesis. Changes in focal adhesions, cytoskeletal organization and gene expression are major responses of endothelial cells to shear stress. Here, we show that activation of the small GTPase Rac is essential for g...

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Bibliografiska uppgifter
Huvudupphovsmän: Tzima, Eleni, Del Pozo, Miguel Angel, Kiosses, William B., Mohamed, Samih A., Li, Song, Chien, Shu, Schwartz, Martin Alexander
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2002
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC139108/
https://ncbi.nlm.nih.gov/pubmed/12486000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf688
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