Altered nucleotide misinsertion fidelity associated with polι-dependent replication at the end of a DNA template

A hallmark of human DNA polymerase ι (polι) is the asymmetric fidelity of replication at template A and T when the enzyme extends primers annealed to a single-stranded template. Here, we report on the efficiency and accuracy of polι-dependent replication at a nick, a gap, the very end of a template...

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Bibliographic Details
Main Authors: Frank, Ekaterina G., Tissier, Agnès, McDonald, John P., Rapić-Otrin, Vesna, Zeng, Xianmin, Gearhart, Patricia J., Woodgate, Roger
Format: Artigo
Language:Inglês
Published: Oxford University Press 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC125476/
https://ncbi.nlm.nih.gov/pubmed/11387224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.11.2914
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