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A degradation signal located in the C-terminus of p21(WAF1/CIP1) is a binding site for the C8 α-subunit of the 20S proteasome
The cyclin-dependent kinase inhibitor p21(WAF1/CIP1) is a key regulator of cell-cycle progression and its expression is tightly regulated at the level of transcription and by proteasome-dependent proteolysis. The turnover of p21(WAF1/CIP1) by proteasomes does not always require the ubiquitylation of...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2001
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125454/ https://ncbi.nlm.nih.gov/pubmed/11350925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.10.2367 |
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