Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation
The p53 tumor suppressor is inhibited and destabilized by Mdm2. However, under stress conditions, this downregulation is relieved, allowing the accumulation of biologically active p53. Recently we showed that c-Abl is important for p53 activation under stress conditions. In response to DNA damage, c...
Kaydedildi:
| Yayımlandı: | EMBO J |
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| Asıl Yazarlar: | , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2002
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125401/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12110584/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf384 |
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