Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation

The p53 tumor suppressor is inhibited and destabilized by Mdm2. However, under stress conditions, this downregulation is relieved, allowing the accumulation of biologically active p53. Recently we showed that c-Abl is important for p53 activation under stress conditions. In response to DNA damage, c...

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Dettagli Bibliografici

Pubblicato in:	EMBO J
Autori principali:	Goldberg, Zehavit, Vogt Sionov, Ronit, Berger, Michael, Zwang, Yaara, Perets, Ruth, Van Etten, Richard A., Oren, Moshe, Taya, Yoichi, Haupt, Ygal
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2002
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125401/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12110584/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf384
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