The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

Transcriptional repression mediated through histone deacetylation is a critical component of eukaryotic gene regulation. Here we demonstrate that the class II histone deacetylase HDAC4 is covalently modified by the ubiquitin-related SUMO-1 modifier. A sumoylation-deficient point mutant (HDAC4-K559R)...

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Bibliographic Details

Published in:	EMBO J
Main Authors:	Kirsh, Olivier, Seeler, Jacob-S., Pichler, Andrea, Gast, Andreas, Müller, Stefan, Miska, Eric, Mathieu, Marion, Harel-Bellan, Annick, Kouzarides, Tony, Melchior, Frauke, Dejean, Anne
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2002
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125385/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12032081/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.11.2682
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