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The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase
Transcriptional repression mediated through histone deacetylation is a critical component of eukaryotic gene regulation. Here we demonstrate that the class II histone deacetylase HDAC4 is covalently modified by the ubiquitin-related SUMO-1 modifier. A sumoylation-deficient point mutant (HDAC4-K559R)...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2002
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125385/ https://ncbi.nlm.nih.gov/pubmed/12032081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.11.2682 |
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