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The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

Transcriptional repression mediated through histone deacetylation is a critical component of eukaryotic gene regulation. Here we demonstrate that the class II histone deacetylase HDAC4 is covalently modified by the ubiquitin-related SUMO-1 modifier. A sumoylation-deficient point mutant (HDAC4-K559R)...

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Publicado no:EMBO J
Principais autores: Kirsh, Olivier, Seeler, Jacob-S., Pichler, Andrea, Gast, Andreas, Müller, Stefan, Miska, Eric, Mathieu, Marion, Harel-Bellan, Annick, Kouzarides, Tony, Melchior, Frauke, Dejean, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125385/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12032081/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.11.2682
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