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T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1

The nuclear pore complex (NPC) is the sole and selective gateway for nuclear transport, and its dysfunction has been associated with many diseases. The metazoan NPC subcomplex RanBP2, which consists of RanBP2 (Nup358), RanGAP1-SUMO1, and Ubc9, regulates the assembly and function of the NPC. The role...

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Wedi'i Gadw mewn:
Prif Awduron: Yujiao He, Zhiguo Yang, Chen-si Zhao, Zhihui Xiao, Yu Gong, Yun-Yi Li, Yiqi Chen, Yunting Du, Dianying Feng, Amnon Altman, Yingqiu Li
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications Ltd 2021-06-01
Cyfres:eLife
Pynciau:
t cell receptor
pkctheta
nuclear pore complex
phosphorylation
rangap1 sumoylation
nuclear transport
Mynediad Ar-lein:https://elifesciences.org/articles/67123
Tagiau: Ychwanegu Tag
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