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Multisite protein phosphorylation makes a good threshold but can be a poor switch

Phosphorylation and dephosphorylation play a fundamental role in eukaryotic signaling. Some 30% of proteins are phosphorylated at any time, many on multiple sites, raising the question of how the cellular phosphorylation state is regulated. Previous work for one and two phosphorylation sites has rev...

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Détails bibliographiques
Auteur principal: Gunawardena, Jeremy
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2005
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1253599/
https://ncbi.nlm.nih.gov/pubmed/16195377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507322102
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