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Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

Mitogen-activated protein kinase (MAPK) cascades can operate as bistable switches residing in either of two different stable states. MAPK cascades are often embedded in positive feedback loops, which are considered to be a prerequisite for bistable behavior. Here we demonstrate that in the absence o...

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Bibliografiska uppgifter
Huvudupphovsmän: Markevich, Nick I., Hoek, Jan B., Kholodenko, Boris N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2004
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172246/
https://ncbi.nlm.nih.gov/pubmed/14744999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200308060
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