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Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis
The misfolding of transthyretin (TTR), including rate-limiting tetramer dissociation and partial monomer denaturation, is sufficient for TTR misassembly into amyloid and other abnormal quaternary structures associated with three amyloid diseases: senile systemic amyloidosis, familial amyloid polyneu...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2005
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1253540/ https://ncbi.nlm.nih.gov/pubmed/16195386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501609102 |
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