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The Ca(2+) concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action
The mechanism of action of the anti-apoptotic oncogene Bcl-2 is still largely obscure. We have recently shown that the overexpression of Bcl-2 in HeLa cells reduces the Ca(2+) concentration in the endoplasmic reticulum ([Ca(2+)](er)) by increasing the passive Ca(2+) leak from the organelle. To inves...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2001
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125256/ https://ncbi.nlm.nih.gov/pubmed/11387204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.11.2690 |
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