Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription

The Dnmt3a DNA methyltransferase is essential for mammalian development and is responsible for the generation of genomic methylation patterns, which lead to transcriptional silencing. Here, we show that Dnmt3a associates with RP58, a DNA-binding transcriptional repressor protein found at transcripti...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Fuks, François, Burgers, Wendy A., Godin, Nadia, Kasai, Masataka, Kouzarides, Tony
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125250/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11350943/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.10.2536
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