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Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription
The Dnmt3a DNA methyltransferase is essential for mammalian development and is responsible for the generation of genomic methylation patterns, which lead to transcriptional silencing. Here, we show that Dnmt3a associates with RP58, a DNA-binding transcriptional repressor protein found at transcripti...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125250/ https://ncbi.nlm.nih.gov/pubmed/11350943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.10.2536 |
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