Allosteric interactions between GB1 andGB2 subunits are required for optimalGABAB receptor function

Recent studies on G-protein-coupled receptors revealed that they can dimerize. However, the role of each subunit in the activation process remains unclear. The γ-amino-n-butyric acid type B (GABA(B)) receptor is comprised of two subunits: GB1 and GB2. Both consist of an extracellular domain (ECD) an...

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Detalles Bibliográficos

Publicado en:	EMBO J
Principais autores:	Galvez, Thierry, Duthey, Béatrice, Kniazeff, Julie, Blahos, Jaroslav, Rovelli, Giorgio, Bettler, Bernhard, Prézeau, Laurent, Pin, Jean-Philippe
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 2001
Assuntos:	Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125244/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11331581/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.9.2152
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