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Mutator Phenotype Resulting from DNA Polymerase IV Overproduction in Escherichia coli: Preferential Mutagenesis on the Lagging Strand
We investigated the mutator effect resulting from overproduction of Escherichia coli DNA polymerase IV. Using lac mutational targets in the two possible orientations on the chromosome, we observed preferential mutagenesis during lagging strand synthesis. The mutator activity likely results from exte...
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| Main Authors: | , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Microbiology
2005
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| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1251572/ https://ncbi.nlm.nih.gov/pubmed/16166552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.187.19.6862-6866.2005 |
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