Mutator Phenotype Resulting from DNA Polymerase IV Overproduction in Escherichia coli: Preferential Mutagenesis on the Lagging Strand

We investigated the mutator effect resulting from overproduction of Escherichia coli DNA polymerase IV. Using lac mutational targets in the two possible orientations on the chromosome, we observed preferential mutagenesis during lagging strand synthesis. The mutator activity likely results from exte...

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Détails bibliographiques
Auteurs principaux: Kuban, Wojciech, Banach-Orlowska, Magdalena, Bialoskorska, Malgorzata, Lipowska, Aleksandra, Schaaper, Roel M., Jonczyk, Piotr, Fijalkowska, Iwona J.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2005
Sujets:
Genetics and Molecular Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1251572/
https://ncbi.nlm.nih.gov/pubmed/16166552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.187.19.6862-6866.2005
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