Mutator Phenotype Resulting from DNA Polymerase IV Overproduction in Escherichia coli: Preferential Mutagenesis on the Lagging Strand

We investigated the mutator effect resulting from overproduction of Escherichia coli DNA polymerase IV. Using lac mutational targets in the two possible orientations on the chromosome, we observed preferential mutagenesis during lagging strand synthesis. The mutator activity likely results from exte...

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Bibliographische Detailangaben
Hauptverfasser: Kuban, Wojciech, Banach-Orlowska, Magdalena, Bialoskorska, Malgorzata, Lipowska, Aleksandra, Schaaper, Roel M., Jonczyk, Piotr, Fijalkowska, Iwona J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Genetics and Molecular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1251572/
https://ncbi.nlm.nih.gov/pubmed/16166552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.187.19.6862-6866.2005
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