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Increased Fidelity Reduces Poliovirus Fitness and Virulence under Selective Pressure in Mice

RNA viruses have high error rates, and the resulting quasispecies may aid survival of the virus population in the presence of selective pressure. Therefore, it has been theorized that RNA viruses require high error rates for survival, and that a virus with high fidelity would be less able to cope in...

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Detalhes bibliográficos
Main Authors: Pfeiffer, Julie K., Kirkegaard, Karla
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1250929/
https://ncbi.nlm.nih.gov/pubmed/16220146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0010011
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